The short version
- Extensions often focus on longer-term safety and tolerability.
- They are usually not blinded.
- Results answer different questions than the main trial.
Why they exist
Researchers and participants may want longer follow-up once the main question is answered.
What changes
Blinding may end, and some people switch from comparison products to the study product.
How to read them
Look for how many people continued and why others stopped.
Not a second main trial
Extensions complement the main study; they do not replace it.
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